You should be able to hook the BES to the remote mailbox server from how I understand it. I think the issue will revolve around getting an account that has high enough permissions. The BES server connects as an administrator to the mailbox server and then administratively logs into each mailbox to check for new messages / calendars. Thus you cannot be a 'domain admin' and still complete the task.
Just my two cents!
Cheers,
Dusty
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