See the end of this post for the path from 4.5 to 6.0:
ZCS 6.0.5 & 5.0.22 Are Live
I'm guessing you'll want to go all the way up to 6.0.7 before doing the conversion to 64-bit and RHEL 5 (hopefully it means a few years of bug fixes and experience doing conversions), but someone else will have to comment on that..