I suggest you to do some tests in advance, and above all whatch what your future users use of Outlook or whatever client they have.
My experience is that with 5.x series could easely become a complete disaster, and with 6.0 could be feasable, I have to check if the new technology for Calendar alarms that should popup ZWC (Zimbra Web Clients) even if not in foreground.
There are many features that people take as granted since their usual (primitive) client do, that they then are very angry when disconver there aren't in zimbra and they did not told you were fundamental since they thought are "obvious".
For example, if you connect to POP3 through "External account" setting, there is no "auto polling" of mails, has to be done manually pressing a button.
There is no "recipe confirmation". You can hardly have multiple accounts available with single login (you can "mimic" with Parent/child relation, but is something that requires shell command intervantion by you). You can attach multiple files with a multiple selection (i.e. select the first file, press shift and click the last one) etc..
So, since ZWC does not replace usual client functionality, also in area that is consider important in normal workflow, you have to be sure you are installing to the right people for zimbra (seems there are many).
At least, this is my personal experience
