I have found a few articles on this... some say to disable AS/AV under Global Settings some say to we can whitelist some ip's.
I have tried those solutions and neither of them work. When I do either it can no longer connect to that port and they automatically goto deferred.
We would be fine if we could either disable spam/anti-virus for outgoing or all-together as we don't really use this for inbound mail.
Release 4.5.9_GA_1454.UBUNTU6 DEBIAN4.0 FOSS edition