Delete the %AppData% Zimbra folders...
What I've found out, if you run the zdrun.vbs from the command line using cscript, then the missing path is shown (causing 800A004C).
Originally Posted by tokarevps
Following this, it helps to goto %AppData% with Windows Explorer and to locate the Zimbra folder. Therein you can see three subfolders, at least on my Windows 7 Professional x64 installation. Moving or deleting those folders away will reset your user Zimbra settings. At a new start Zimbra Desktop will launch and has to be re-configured.
I assume that this behaviour is caused by having the users' data outside the standard path C:\Users in this case in D:\Benutzer\USER\... (which is German for Users).
I hope this helps you folks to solve or at least work around the issue.