I am on LION and am getting this error too :
Script: file:///Applications/Zimbra%20Desktop/macos/prism/Prism.app/Contents/Resources/modules/WebAppProperties.jsm -> file:///Users/~/Library/Zimbra%20Desktop/zdesktop.webapp/webapp.
js:128
I also get the "Cannot connect to zimbra server" error....
Any thoughts please? I seem to have tried everything.