I run an Open-E SAN DOM which is basically a vendor provided embedded linux setup like openfiler on a 512mb flash disk on module with our production zimbra environment.
When I was scoping our hardware needs for our mail setup I decided I did not need the expense of a fibre SAN like I do for our large ERP / SQL infrastructure.
The hardwire for my Open-E SAN is;
Chenbro 3U Chassis w/ 8x SATA Hot Swap backplane
Zippy 650W Redundant PSU's
8x 500GB 7200RPM Sata HDD's
Tyan Thunder K8S MB
Dual GigaNics
2x Opteron 252 CPU's
4GB Memory
AMCC (3ware) 8 Port Sata Raid Controller w/ BBU
Open-E Enterprise iSCSI DOM
The hardwire for my Mail Server is;
Chenbro 2U Chassis w/ 6x SAS Hot Swap backplane
Zippy 600W Redundant PSU's
6x 73GB SAS 10k RPM HDD's
Tyan Thunder K8S MB
Dual GigaNics
2x Opteron 880 CPU's
4GB Memory
Qlogic iSCSI 4050C Initiator
I opted for a Hardware HBA over a software iscsi initiator on the mail server. The Qlogic presents the iSCSI target on the SAN as a normal scsi device (sdc1) which I have mounted to /export/zimbra.
Zimbra is installed as per normal in /opt but I have the mail store pointing to /export/zimbra.
I have used this setup for 225 NE version users for the past 2+ years on CentOS 4.3, currently on 5.0.5 of ZM. Both machines have an uptime of 680+ days without a single issue.
I have the SAN snapshot nightly to a 3ware sidecar device in IT;
Digicor -External Serial ATA RAID Storage Box : RD-SIDECAR from 3WARE
I have this shared out via NFS as well that gets mounted on the mail server for backups. This is a 4TB unit.
This entire setup cost less then one of my single fibre san devices serving my SQL enviroments, and has proven a great success.
I'd say you can achieve just the same using openfiler without complaint, btw EMC came out to benchmark it against one of their tier units and this won. EMC wanted 45+k for their unit at the time.
** The SAN provides 1.8TB usable and is split into 3 targets for reference only a 500gb Target serves the mail server, our current mail store is 345gb. Only ZM is running on the mail server.