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Hooo man please!!!...was a question for rookies?? ... the most rare thing, I've always changed this file, and so far it had worked properly, at least for previous Zimbra version.
Changing amavisd.conf might work temporarily, but it probably gets overwritten when you stop/start zimbra (or zmamavisdctl, or anything that calls zmamavisdctl).
Even amavisd.conf.in may get overwritten on upgrade, so if you change it, I'd recommend making a backup of the changes.