well you can modify postfix to not queue messages if it's a non existant domain. by default it will rettry for 5 days
the downside to this is it can lead to legitimate e-mails not being delivered if the recipient is having a network problem. like if i run business.com and my dns servers go offline for some reason for just a few hours, if you try to send an e-mail to
joe@business.com normally it would get an unknown host, then retry in a few hours and then my dns servers would be up and i'd get the e-mail. if you make the change then it will error and say unknown host.