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It's been covered many times in the forums. You've connected to the Zimbra server with a fat IMAP client such as Thunderbird, you'll need to connect again with that client and run an compact (pr expunge) of the folders.
Actually Bill I see this issue a lot! It appears to manifest itself when you completely empty a folder (using right click on folder method) the number of items unread still shows. Refreshing the browser resolves the problem. I have now installed Firebug so when it happens again will try and see what is causing it. Note: I only use the Ajax client and have never connected with another client.