Oh, sorry for my (considerable) confusion.

Are you able to access the UI at all? What does a command-line zmcontrol status tell you?
However these diagnostic steps may still be worth doing for you too:
Quote:
Try to log in from one of the failing machines. Then tail /var/log/zimbra.log and see if you can find any indication of the event that might show you the success or failure.
At the risk of going for the painfully obvious, you *have* done a stop and restart of Zimbra services, yes? Any errors show up in zimbra.log during the restart?
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And since you said CentOS 5 (and without trying to bring up a lot more heat) have you checked the perl issue that caused all the headaches a couple days back?